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A patient with a rotator cuff strain, for example, may continue cycling, swimming with modified strokes, or running without significantly impairing the healing environment
The activation of these junctions may also induce long-term structural changes, such as the formation of tight associations with pericytes (which may encompass gene expression modulation), determining the stability and maturation of the vasculature [45], or short-lasting effects, like transient changes in endothelial permeability to solutes and circulating cells [46,47,48]
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Contributing factors may include collagen sensitivity, chemical additives in collagen supplements, and contaminated natural collagen sources
Future research directions are also discussed to advance our understanding and treatment of free radical-associated diseases
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