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The NAD + /NADH ratio is critical in maintaining redox homeostasis and is a key indicator of cellular health and mitochondrial metabolism [66, 67]

Based on various meta-analysis studies across the world, the prevalence of DPN in Africa was found to be 38% in type-2 diabetic patients, 21% in Asia, mostly in India, 46.5% in Caribbean and South America, with high prevalence in Brazil and based on a population based study in the US around 14% younger adults and 42% older adults were suffering from DPN (Savelieff et al

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