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What we know today comes from two sources: controlled clinical trials (STEP, SELECT, SURMOUNT) and the collective experience of over 1.5 million Americans using these medications as of January 2026

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Side Effect 5: Systemic Effects Systemic reactions may include fatigue, anxiety, and numbness in extremities

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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program