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In preclinical studies, GLP-1 receptor agonists reduce self-administration of opioids, attenuate drug-seeking after periods of abstinence, and blunt stress-induced relapse

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Many people report: Reduced appetite within 1 to 4 weeks Less interest in snacking within the first month Improved portion control during the first several weeks Measurable weight loss after several weeks to a few months Continued weight loss over 6 to 12 months A typical timeline looks like this: If youre wondering how fast retatrutide works, its important to remember that appetite suppression often occurs before significant weight loss appears on the scale

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