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When GLP-1 reaches the pancreas, it binds to GLP-1 receptors (GLP-1R) expressed on the pancreatic cells, stimulating insulin release
Discussion This is the case of a 44 year old man with extreme, refractory obesity who successfully underwent a 21 day water fast in combination with GLP-1 treatment prior to bariatric surgery
3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Du et al., 2022
