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Many patients report smoother tolerance curves and sustained weight loss with this conservative dosing strategy, particularly those sensitive to rapid satiety changes or nausea

The 12 mg dose produced 28.7% weight loss over 68 weeks, and the 9 mg dose achieved 26.4%

Budiman ME, Bubenik JL, Miniard AC et al (2009) Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation

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M., Silva, M