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GLP-1 medications like Ozempic can directly lower leptin levels and prevent the leptin rise that typically causes weight regain after weight loss, but should be combined with the other interventions for lasting success

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Fasanmade OA, Odeniyi IA, Ogbera AO

By optimizing these circuits, native GLP-1 production and metabolic flexibility naturally rise, allowing for the tapering of medication as the body reclaims autonomy