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In this study, a 24-h Holter ECG recording was performed at baseline, after the maximum daily dose for each drug (lixisenatide 20 g, liraglutide 0.9 mg) had been administered for at least 1 week following completion of the up-titration period

Sequential versus simultaneous initiation : Many clinicians prefer establishing tirzepatide tolerance and efficacy before adding other therapies, allowing clearer attribution of benefits and adverse effects

While regular sun protection can help prevent them from darkening, freckles typically remain a natural skin feature unless specific treatment is used to reduce their appearance