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Unlike semaglutide, which targets only the GLP-1 pathway, tirzepatide simultaneously activates both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor
It also produced large, dose-dependent improvements in insulin-resistance biomarkers: at the highest dose, HOMA2-IR fell by roughly 69% and fasting insulin by roughly 71% from baseline, with the magnitude of insulin reduction closely tracking the fall in liver fat
How long does it take to see results from GLP-1 therapy
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