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383 In MPP + -induced PD cell models and primary DA neurons, SIRT1 enhances mitochondrial biogenesis through the deacetylation of PGC-1, providing neuroprotection

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It works by supporting synaptic communication, modulating serotonin and dopamine pathways, and boosting antioxidant defenses in the brain

Because terminology, peptide form, assay design, and reporting quality vary across the historical literature, study conclusions should remain tied to the exact sequence, disulfide configuration, counterion or salt form, formulation, species, route, exposure period, and endpoint used