GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

Factors affecting how fast oral semaglutide works How fast oral semaglutide works for weight loss and diabetes can depend on several factors, including adherence to treatment, other health conditions, the dosage prescribed, and lifestyle considerations
Some countries and states in the US mandate a prescription to purchase it, due to the potential misuse or improper administration
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Of the 17,160 patients enrolled in this trial, 1025 (6%) had PAD