is semaglutide a glp-1 Review on Semaglutide: An Oral Glucagon-Like Peptide 1 Receptor Agonist in Management of Type 2 Diabetes Mellitus | Diabetes Therapy Benefits of Semaglutide GLP-1 Injections

doi: 10.1016/j.ntt.2021.106984 89 WangJJohnsonTSahinLTassinariMSAndersonPOBakerTEet al

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Regarding fibrosis, while direct anti-fibrotic mechanisms are less established, preclinical studies indicate that GLP-1 RAs could suppress fibrogenic cell activation and reduce expression of pro-fibrotic genes encoding extracellular matrix proteins, potentially facilitating fibrosis regression in conjunction with improvements in steatosis and inflammation [29-32]

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The cysteine thiol (-SH) group provides potent nucleophilic and reducing properties, allowing GSH to neutralize electrophiles and free radicals