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22 Based on the favorable bioavailability of the amide, N-acetylcysteine amide (NACA), over the acid, NAC, 23 and likely its methyl ester, 24 the pursuit of NACA therapy for treatment of HCCAA is warranted
To accomplish the desired amide bond formation, we must first deactivate all extraneous amine functions so they do not compete for the acylation reagent
Given the high consumption of free glutamine by intestinal cells, glutamine dipeptides have been studied as an alternative for transposing the intestinal barrier and increasing the bioavailability of this amino acid to cells of the immune system
Finally, the specific antioxidant mechanisms involved need further exploration
Sequence variation in dichloromethane dehalogenases/glutathione S-transferases
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