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The regulation of OPA1 in cells is complex and involves its transcriptional level, activation state, and proteolytic cleavage
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This is supported at least in part at the biochemical level: the Km of L-cysteinyl-tRNA synthetase towards cysteine, which directs cysteine to translational machinery, is less than one tenth of that for other enzymes of cysteine metabolism such as GCS or cysteine dioxygenase 22
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