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7 Hydroxocobalamin has a homocysteine-reversing property by converting homocysteine to beneficial methionine that helps with energy production and is essential for the nervous system and normal brain function 7 8 Vitamin B12 deficiency can increase the homocysteine levels resulting in impaired cognitive function, stroke, Alzheimer's disease, cardiovascular disorders, and osteoporosis
Importantly, these changes were observed without significant reductions in food consumption, pointing to enhanced energy metabolism rather than appetite suppression as the primary mechanism
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Individuals with known B12 deficiencies, or those prone to a potential deficiency due to their lifestyle, must supplement vitamin B12
Last reviewed: May 30, 2026 Last updated: May 30, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
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