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In addition, SHMT2 depletion has been shown to induce mitochondrial respiratory chain deficiency by reducing basal respiration and respiratory capacity, decreasing NAD + /NADH ratios, and lowering the expression levels of respiratory complex I, IV, and V proteins [93]

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In colorectal cancer, the AFG3L2SLC25A39 axis stabilizes mitochondrial GSH and promotes proliferation [34]

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Recovery is possible with appropriate, evidence-based treatment tailored to individual needs

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