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This inhibition leads to a significant reduction in mitochondrial ATP production (with an IC50 of 5.3 M) and oxygen consumption (with an IC50 of 10.9 M), effectively impairing over 90% of mitochondrial function at certain concentrations [158]
Hjerpsted JB, Flint A, Brooks A, Axelsen MB, Kvist T, Blundell J (2018) Semaglutide improves postprandial glucose and lipid metabolism, and delays first-hour gastric emptying in subjects with obesity
X.Da Silva BarrosR
The EVOKE trials are expected to be completed in September 2025
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