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Glutathione may interact with certain chemotherapy agents and other medications

An overactive cytokine response is associated with chronic inflammatory conditions and was a notable factor in severe COVID-19 cases, where studies found that many seriously ill patients had significantly depleted glutathione stores

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For the mass spectrometry, the data-dependent MS 2 scan conditions were applied in both positive and negative mode: the scan range was from m/z 2501500, resolution was 60,000 for MS, and 30,000 for DDMS 2 (top 10), and the AGC target was 3E 6 for full MS and 1E 5 for DDMS 2 , allowing ions to accumulate for up to 200 ms for MS and 50 ms for MS/MS