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SARS-CoV-2 is also genetically related to other endemic human coronaviruses that cause milder infections: HCoV-HKU1 (~52% sequence identity), HCoV-OC43 (~51%), HCoV-NL63 (~49%) and HCoV-229E (~48%) 1

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In addition to metabolic signaling, microbial-associated molecular patterns (MAMPs) engage the immune system through recognition by toll-like receptors (TLRs) on antigen-presenting cells, lymphocytes, fibroblasts, and epithelial cells [53]

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According to the IDF, the overall diabetes expenditure in Europe among the population aged 20-79 years was USD 156 billion, and it is expected to increase to USD 174 billion by 2040