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While the trials were negative clinically, presenters and discussants noted biomarker changes consistent with reduced neuroinflammation (e.g., decreases in highsensitivity CRP) and other Alzheimersrelated signalsmodest but statistically significant effects that did not yield measurable cognitive benefit

Kwon et al., 2019), the mechanistic underpinnings for most metabolites remain undefined, necessitating further investigation to delineate the molecular pathways of metabolite-driven lung damage in DM

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