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These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells

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Kim Y, Park IH, Shin J, Choi J, Jeon C, Jeon S, et al

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Additional warnings include risk of suicidal behavior or thinking, acute kidney injury in patients who experience severe adverse gastrointestinal reactions, and reduced efficacy of oral contraceptives