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PMCRegenics 2
BDNF, a neurotrophin strongly induced by exercise, supports neuronal survival and synaptic integrity while counteracting inflammation-associated neurodegeneration, both directly and indirectly through suppression of microglial activation (147, 156160)
It is still unclear whether it passes directly through cell membranes
3), we subsetted tier-1 and tier-2 targets to those occurring in at least 5% of the cells for each data set for which tier-1 targets could be identified (high-confidence tier-1 and tier-2 targets, Supplementary Data 5)
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