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Approval was based on phase 3 clinical data particularly from the OASIS 4 trial showing
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The signal for acute kidney injury (675 cases) was more prominent in elderly and overweight groups, potentially linked to metformins contraindication in renal impairment 34 and the dehydration effects of GLP-1RAs 40 , highlighting the need for strict baseline renal function screening and monitoring of blood volume status
Victoza/Saxenda (liraglutide) These daily injectable GLP-1 medications fall in the middle: After first use, they can be kept at room temperature for up to 30 days
These results greatly exceed those of previous weight loss drugs and approach the effect of some bariatric surgical procedures
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