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Document adverse reactions immediately

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The total weekly dose remains the same, but the peak plasma concentration is lower, which can reduce gastrointestinal side effects

Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials