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Stacking multiple GLP-1 agonists together, such as semaglutide and tirzepatide, is generally not recommended due to overlapping mechanisms and increased side effect risk
The FDA's 2024 review found no published human pharmacokinetic study that formally characterized the subcutaneous route, so these amounts are anecdotal rather than an approved clinical protocol
A lack of reported harm is not proof of safety
Jorgensen JO, et al
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