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Our studies of the effects of age and APOE in the cerebrovasculature showed that with age, total acylcarnitine levels increased in the cerebrovasculature of E2 and E3 mice but not in E4 mice, this was also observed in the brain parenchyma

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

The drugs, originally designed to treat diabetes and found to promote weight loss, have also shown benefits for heart risks, sleep apnea and alcohol and substance abuse

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Those who remained on therapy for a full year lost about 12%, falling short of clinical trial averages of 15 to 20%