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The tricarboxylic acid (TCA) cycle is the central hub of metabolism, participating in both catabolism and anabolism
Katunina EA, Blokhin V, Nodel MR et al
Because abnormal epigenetic marks disrupt the expression of specific tumor suppressor genes in cancer cells, compounds that re-induce their transcription, like those inhibiting HDACs, can potentially promote differentiation and apoptosis in transformed (precancerous) cells (37)
Vance, 2014
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