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In such applications, cholesterol loading into the membrane is dictated by cholesterols solubility limit, which strongly depends on the phospholipid headgroup, e.g., phosphatidylcholine (PC) vs phosphatidylethanolamine (PE) or phosphatidylserine (PS) [ L O ) phase that is rich in saturated lipids and cholesterol and a liquid-disordered ( L D ) phase that is predominantly formed by unsaturated and/or short chain lipids [ L O domains and looser packing in the L D regions

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However, we can achieve more robust skin tightening with devices that are designed specifically for that purpose, namely, Sofwave, Ulthera, and Thermage