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8Allen J, Bradley RD
Observational analyses and randomized clinical trials consistently report nausea, vomiting, diarrhea, constipation, and abdominal discomfort as the most common symptoms, although the distribution of events varies
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Lillys small-molecule GLP-1 agonist orforglipron (brand Foundayo) also gained FDA approval in April 2026 for weight loss and is expected to launch in 2027, marking a breakthrough as the first non-peptidic GLP-1 pill ( [35] )
doi: 10.1038/nrd2359
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