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demonstrated in 2001 that AOD-9604 stimulates lipolysis in adipose tissue without activating the growth hormone receptor, a finding that separated its fat-metabolizing action from GH-related proliferative risks [1]
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Clinical trials did not identify sleep disruption as an AOD 9604 side effect
That said, the combination itself has not been clinically validated there are no controlled human trials of this specific blend, and the supporting data for each peptide is largely preclinical (animal) work and anecdote
It should be incorporated into a suitable finished formulation at the recommended use level rather than applied directly to the scalp or skin
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