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However, some individuals may experience mild side effects, such as gastrointestinal upset
T., Yanik K
Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92
Undermethylation Some patients with an undermethylated mood pattern report worsening of depression, agitation or obsessive symptoms with folic acid or methylfolate despite their biochemical role in one-carbon metabolism
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