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Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus
In experimental models, research models demonstrate altered insulin sensitivity and glucose handling parameters, with plasma total cholesterol levels showing reductions
More recent literature has revisited the fragment in the context of combination studies, where researchers pair it with secretagogues to separate direct adipose effects from endogenous GH-axis activation
With oral vitamins it can take days or weeks of daily dosing to build up the same effect
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