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Considering the complex landscape of obesity management, integrating GLP-1 and GIP agonists offers a promising pathway toward achieving sustainable weight loss and improving overall health outcomes

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Discussion As there is a continuous need for increased potency on weight loss, we investigated the pharmacological potential of combination therapy using the highly potent DACRA KBP-089 and the GLP-1 analog liraglutide for obesity

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In contrast, chronic elevations in TMAO, a metabolite derived from LC, have been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly in older adults with compromised renal function [64, 65]