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The multiple linear regression analysis was performed using IBM SPSS statistics software (version 19)

Baseline assessment should include evaluation of renal function, particularly for direct oral anticoagulants (DOACs) which require dose adjustments in renal impairment

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The latter reaction is assumed to be one of the primary regulation points in the sulfate reduction, since the activity of APS reductase is the lowest of the enzymes of the sulfate reduction pathway and it has a fast turnover rate