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Peptide molecular weight is the total mass of a peptide, calculated by summing the molecular weights of its amino acid residues and terminal groups

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One of the main criteria for classifying variants is to categorize them into null variants, which result in a non-functional protein or no protein at all, and missense variants, which produce a protein with an altered amino acid sequence that may retain residual function, have reduced function, or even acquire a different function from the original protein