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Most of the available data reporting on CNS penetrants from GLP-1 RAs derives from preclinical studies, which may generalizeto humans
For these reasons, GLP-1 analogues and DPP-4 inhibitors were synthesized to prolong the half-life of GLP-1
The antioxidant properties of minocycline help protect neurons from mitochondrial DNA damage and GSH depletion [157]
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