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Wegovy (semaglutide) is FDA-approved to help with long-term weight management in adults and in teens 12 and older with obesity
AOD 9604 works, but it's not dramatic in the short term
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Peripherally administered GLP-1R and GIPR agonists have also been shown to localize in CVOs, with limited labelling in brain regions shielded by the bloodbrain barrier 13,54,55
This same principle applies when comparing semaglutide, tirzepatide, and future medications such as retatrutide
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