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T cell-specific genetic ablation of Pcyt2 , which encodes CTP: phosphoethanolamine cytidylyltransferase, but not of Pcyt1a , which mediates the cytidine diphosphate-choline pathway, impairs T FH cell differentiation, leading to diminished humoral immune responses ( T cell-derived acetylcholine (ACh) has long been studied as a crucial immune regulator