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Active or unstable major depressive disorder (MDD) or other severe psychiatric illnesses (e.g., schizophrenia, bipolar disorder) within the past two years

In addition, another research revealed a decrease in iron deposition in the hippocampus, which improved synaptic plasticity and decreased damage to hippocampus neurons, encouraging the restoration of cognitive function in db/db mice [104]

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p = 0.02) (Fig