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Immunity 50 , 432445.e7 (2019)
According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver
2017;12:e0184026
Notably, microbiota reintroduction into GF mice partially restores immune cell populations and function, depending on bacterial strain composition and the timing of colonization [34, 35]
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