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When serotonin levels fluctuate excessively, it results in mood instability and contributes to chronic mental health conditions, making regulation necessary for emotional balance

The right temporal muscle was dissected, the temporal bone dried, and a laser Doppler flow (LDF) probe was attached to the temporal bone to monitor regional cerebral blood flow (rCBF) during the procedure

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The studies began with the determination of the optimal dosing for Cagrilintide in both chow-fed and high-fat diet (HFD)-fed wild-type (WT) mice, followed by analyses of its receptor dependence using receptor activity-modifying protein (RAMP) knockout (KO) models, and mechanistic studies involving neuronal activation and gene expression profiling [2]