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It is a major risk factor for heart disease, heart attack, stroke, and kidney disease

However, it can sometimes cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, especially when starting treatment or increasing the dose

AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) consensus serum creatinine criteria as either an increase in serum creatinine of 0.3 mg/dL (26.5 mol/L) within 48 hours or an increase to 1.5 times baseline within the preceding 7 days ( Cardiovascular outcomes were evaluated using a prespecified composite endpoint

Inability to lose body fat

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