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H., Sankaranarayanan, V

Some small studies have reported reduced sleep latency and improved sleep efficiency with L-carnitine supplementation, and researchers have proposed that its role in energy metabolism might indirectly influence neurotransmitter activity tied to sleep-wake regulation

Some patients may experience: Mild injection site reactions (redness, slight swelling) Temporary drowsiness (related to increased melatonin production) Mild headache in the first few days Serious adverse effects are rare in published literature

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[2] [12] These effects, combined with reduced caloric intake due to appetite suppression, can alter metabolism, though there is no direct evidence linking these changes to cold extremities specifically with tirzepatide