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Ashtary-Larky D, Bagheri R, Bavi H, Baker JS, Moro T, Mancin L, et al
ESM Fig
documented efficacy in improving desire scores and reducing distress associated with low libido Low libido in postmenopausal women: off-label use investigated where hormonal changes have reduced sexual desire and standard hormone therapy has not fully addressed the desire component Low sexual desire and erectile dysfunction in men: off-label use investigated for men where low libido (desire component) coexists with erectile difficulty, either as monotherapy or alongside PDE5 inhibitors Sexual dysfunction with psychological or stress-related components: PT-141's central mechanism may be particularly relevant where desire is suppressed by psychological factors rather than purely vascular ones Patients who have not responded adequately to PDE5 inhibitors alone: PT-141 adds the central desire component that PDE5i do not address PT-141 is the only FDA-approved medication that treats low sexual desire through a central neural mechanism rather than a peripheral vascular one
According to UCLA Health ( berberine may significantly reduce weight, BMI, and waist circumference in people with overweight
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