tirzepatide surmount-1 trial weight loss non-diabetic as Compared with Semaglutide for the Treatment of Obesity Tirzepatide after intensive lifestyle intervention

These findings challenge the prior notion that GIP might be obesogenic and instead suggest that pharmacological activation of GIPR could offer therapeutic benefits for weight reduction

Giustarini, D., Dalle-Donne, I., Milzani, A

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However, GLP-1RAs also have separate effects on appetite regulation mediated by actions on central nervous system centers that result in weight loss 15,16

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