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This is the same directional change sought with FDA-approved therapies like minoxidil, but achieved through a distinct upstream mechanism
Mice that received CJC-1295 obtained higher body weights and length versus placebo-treated animals
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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets
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