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Inhibition studies The effect of metal ions (Cu 2+ , Zn 2+ , Cd 2+ , Ag + , Fe 2+ , Co 2+ , Mg 2+ , Sn 2+ , and Mn 2+ ) on GR activity was determined by measuring its specific activity in the presence of 0.5 mM, 1 mM, or 1.5 mM of each reagent
More advanced cases of obesity or diabetes may need higher doses, though even those patients might benefit from starting low and escalating only if needed
Obesity reviews: an official journal of the International Association for the Study of Obesity, 24(3), e13539
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