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Other than patients who have had their stomachs bypassed, there is also an autoimmune condition known as pernicious anemia that leads to a deficiency of intrinsic factor, lack of ability to absorb vitamin B12 and therefore poor availability of cobalamin (vitamin B12)

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Biochim Biophys Acta , 1797: 12171224, 2010

The quality of the specific finished product may matter more than the delivery category printed on the front label

If you're using a strong retinoid, be especially cautious about adding copper peptides