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According to available research, the two most effective licensed treatments available currently are Wegovy and Mounjaro

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doi:10.1007/s10295-015-1707-5 Watanabe F, Hashizume E, Chan GP, Kamimura A (2014) Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women

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13 In other words, GLP-1 medicines reduce disease complications directly and indirectly in overlapping ways, perhaps most importantly by reducing chronic inflammation