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Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice
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Exploratory endpoints at the time of survey included the percentage of respondents experiencing difficulties with oral semaglutide (for both physicians and individuals with T2D) and any changes from baseline in physicians resistance to prescribing oral semaglutide, along with the point at which physicians changed their resistance to prescribing oral semaglutide
For people taking semaglutide for weight management, this unpredictability could be particularly concerning, as the precision of dosing is key to the treatments success
FIGURE 1 In this view, trials aimed at testing the potential repositioning of these compounds should be designed by also taking into account the mechanism of action of single drugs and potential combination with other drugs or molecules
